Toshihiro Kumabe Selected Research

Germinoma

1/2022	Transcriptome and methylome analysis of CNS germ cell tumor finds its cell-of-origin in embryogenesis and reveals shared similarities with testicular counterparts.
1/2022	12p gain is predominantly observed in non-germinomatous germ cell tumors and identifies an unfavorable subgroup of central nervous system germ cell tumors.
1/2021	So-called bifocal tumors with diabetes insipidus and negative tumor markers: are they all germinoma?
1/2021	Long-term survival of a patient with diffuse midline glioma in the pineal region: A case report and literature review.
7/2018	Indications for salvage surgery during treatment for intracranial germ cell tumors.
1/2017	Extremely Late Recurrence 21 Years after Total Removal of Immature Teratoma: A Case Report and Literature Review.
8/2015	Human chorionic gonadotropin is expressed virtually in all intracranial germ cell tumors.
1/2014	Mutually exclusive mutations of KIT and RAS are associated with KIT mRNA expression and chromosomal instability in primary intracranial pure germinomas.
1/2014	Early response to chemotherapy as an indicator for the management of germinoma-like tumors of the pineal and/or suprasellar regions.
12/2009	Optimal treatment strategy for intracranial germ cell tumors: a single institution analysis.

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Toshihiro Kumabe Research Topics

Disease

57	Neoplasms (Cancer) 09/2022 - 01/2002
36	Glioma (Gliomas) 06/2022 - 01/2002
26	Glioblastoma (Glioblastoma Multiforme) 01/2022 - 01/2002
12	Germinoma 01/2022 - 09/2002
11	Medulloblastoma 01/2021 - 09/2004
11	Brain Neoplasms (Brain Tumor) 01/2020 - 03/2007
10	Astrocytoma (Pilocytic Astrocytoma) 06/2020 - 01/2002
6	Germ Cell and Embryonal Neoplasms (Germ Cell Tumor) 01/2022 - 09/2002
5	Hypoxia (Hypoxemia) 01/2022 - 08/2010
5	Necrosis 12/2016 - 01/2008
4	Neoplasm Metastasis (Metastasis) 01/2019 - 04/2011
3	Hematoma 02/2022 - 11/2014
3	Cysts 01/2022 - 03/2009
3	Moyamoya Disease (Moya-Moya Disease) 01/2021 - 05/2015
3	Teratoma (Teratoid Tumor) 07/2018 - 09/2002
3	Oligodendroglioma 05/2013 - 07/2007
3	Neuroepithelial Neoplasms (Gliomatosis Cerebri) 05/2013 - 08/2008
2	Carcinogenesis 06/2022 - 01/2022
2	Embolism (Embolus) 12/2021 - 06/2019
2	Venous Thromboembolism 07/2021 - 02/2011
2	Ischemic Stroke 01/2021 - 06/2019
2	Hemorrhage 06/2020 - 01/2002
2	Wounds and Injuries (Trauma) 02/2016 - 07/2014
2	Hemangioblastoma 01/2016 - 12/2009
2	Choriocarcinoma 08/2015 - 09/2011
2	Paresis (Hemiparesis) 01/2013 - 04/2010
2	Carcinoma (Carcinomatosis) 04/2008 - 01/2006
1	Testicular Neoplasms (Testicular Cancer) 01/2022
1	Cerebral Infarction 12/2021
1	Lymphopenia (Lymphocytopenia) 12/2021
1	Thrombocytopenia (Thrombopenia) 12/2021

Drug/Important Bio-Agent (IBA)

12	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 06/2022 - 10/2009
10	Carmustine (FIVB)FDA Link 09/2022 - 11/2013
10	Temozolomide (Temodar)FDA LinkGeneric 12/2021 - 11/2008
10	Proteins (Proteins, Gene)FDA Link 01/2021 - 05/2003
9	NimustineIBA 01/2020 - 01/2002
6	Pharmaceutical PreparationsIBA 09/2022 - 07/2012
5	Etoposide (VP 16)FDA LinkGeneric 01/2021 - 09/2002
5	Protons (Proton)IBA 01/2017 - 04/2003
4	GadoliniumIBA 01/2022 - 04/2005
4	Interferon-betaIBA 05/2020 - 05/2003
4	DNA (Deoxyribonucleic Acid)IBA 01/2020 - 11/2006
4	Messenger RNA (mRNA)IBA 08/2015 - 10/2010
4	Cisplatin (Platino)FDA LinkGeneric 04/2013 - 09/2002
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2022 - 06/2013
3	Tumor Biomarkers (Tumor Markers)IBA 01/2021 - 09/2002
3	Telomerase (Telomerase Reverse Transcriptase)IBA 05/2020 - 01/2018
3	LipidsIBA 01/2017 - 04/2005
3	Chorionic Gonadotropin (Human Chorionic Gonadotropin)FDA LinkGeneric 08/2015 - 06/2006
3	Choline (Choline Chloride)IBA 01/2014 - 04/2005
3	Ifosfamide FDA LinkGeneric 04/2013 - 11/2010
2	poliferprosan 20 drug combination carmustine (Gliadel)FDA Link 01/2022 - 01/2014
2	Aspartate Aminotransferases (Aspartate Transaminase)IBA 12/2021 - 11/2010
2	Alanine Transaminase (SGPT)IBA 12/2021 - 11/2010
2	Biological ProductsIBA 07/2021 - 11/2002
2	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 01/2021 - 03/2008
2	NucleotidesIBA 01/2021 - 10/2019
2	MethyltransferasesIBA 05/2020 - 08/2010
2	Bevacizumab (Avastin)FDA Link 12/2016 - 06/2013
2	CytokinesIBA 11/2016 - 02/2015
2	ParaffinIBA 01/2016 - 03/2014
2	Capsules (Microcapsules)IBA 01/2016 - 11/2014
2	Formaldehyde (Formol)FDA Link 01/2016 - 03/2014
2	SteroidsIBA 01/2016 - 12/2013
2	liposomal doxorubicin (Doxil)FDA Link 01/2016 - 11/2008
2	CreatineIBA 01/2014 - 04/2005
2	Amino Acids FDA Link 06/2013 - 10/2009
2	fibrin fragment D (D-dimer)IBA 01/2013 - 02/2011
2	IceIBA 09/2011 - 11/2010
2	RNA (Ribonucleic Acid)IBA 10/2010 - 11/2006
2	Lactic Acid (Lactate)FDA LinkGeneric 08/2010 - 04/2005
2	Alkylating AgentsIBA 08/2010 - 08/2010
2	MicellesIBA 08/2010 - 04/2009
2	N-acetylaspartate (N-acetyl aspartate)IBA 04/2010 - 04/2005
2	deoxyribonuclease gammaIBA 05/2004 - 05/2003
1	AntibodiesIBA 09/2022
1	alpha-hydroxyglutarateIBA 06/2022
1	Ribosomal Proteins (Ribosomal Protein)IBA 04/2022
1	Carbonic Anhydrase IXIBA 01/2022
1	AntigensIBA 01/2022
1	Nonmuscle Myosin Type IIAIBA 01/2022
1	CholesterolIBA 12/2021
1	depatuxizumab mafodotinIBA 12/2021
1	Immunoconjugates (Immunoconjugate)IBA 12/2021
1	ErbB Receptors (EGF Receptor)IBA 12/2021

Therapy/Procedure

29	Therapeutics 12/2021 - 01/2002
28	Drug Therapy (Chemotherapy) 06/2022 - 09/2002
19	Radiotherapy 06/2022 - 01/2002
9	Chemoradiotherapy 12/2021 - 01/2002
5	Craniotomy 01/2019 - 01/2008
4	Combination Drug Therapy (Combination Chemotherapy) 09/2011 - 09/2002
3	Carotid Endarterectomy 07/2016 - 01/2015
3	Adjuvant Chemoradiotherapy 01/2016 - 04/2011
2	Cytoreduction Surgical Procedures 07/2017 - 01/2016
2	Transplantation 02/2015 - 04/2011
2	Immunotherapy 02/2015 - 09/2004
2	Aftercare (After-Treatment) 05/2011 - 08/2008
2	Combined Modality Therapy 04/2011 - 01/2008
1	Endoscopes 02/2022
1	Decompressive Craniectomy 02/2022